Neutrophil activation and NETosis are the major drivers of

mpo netNETs are DNA-containing structures released by neutrophils that incorporate intracellular factors, such as histones, myeloperoxidase (MPO) and elastase. NETs have aNeutrophil extracellular traps (NETs) are extracellular chromatin fibers adorned with antimicrobial proteins, such as myeloperoxidase (MPO), which are extruded from activated neutrophils.